What symptom might suggest central nervous system (CNS) toxicity from chemotherapy?

Confusion or seizures can indicate central nervous system (CNS) toxicity from chemotherapy because these symptoms reflect significant alterations in neurological function. Chemotherapy agents, particularly those with known CNS side effects, can interfere with normal brain activity, leading to changes in cognition, behavior, and motor function. This toxicity can result from direct damage to neuronal cells, vasogenic edema, or metabolic disturbances caused by the metabolites of chemotherapeutic drugs.

The presence of confusion or seizures highlights a potential for severe adverse effects that require immediate evaluation and management. Recognizing such symptoms is crucial, as they may signify the need to adjust treatment plans or provide symptomatic relief to enhance patient safety and well-being during chemotherapy.